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White matter interactome in vascular dementia

Stefan Wendt , Brian A. MacVicar

Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada
* Correspondence: Brian A. MacVicar(bmacvicar@brain.ubc.ca)

Tian et al. combine an immune-competent focal white matter ischemia mouse model with human single-nucleus transcriptomic data to map conserved ligand–receptor interactions in vascular dementia. This cross-species approach identifies Serpine2-LRP1 and CD39-A3AR signaling as potential therapeutic targets for enhancing remyelination and modulating microglial repair functions.

https://doi.org/10.1038/s41422-025-01175-8

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