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Myeloperoxidase: one enzyme, two jobs

Sara Marchese , Andrea Mattevi

Department of Biology and Biotechnology, University of Pavia, Pavia, Italy
* Correspondence: Sara Marchese(sara.marchese@unipv.it)Andrea Mattevi(andrea.mattevi@unipv.it)

The key neutrophil enzyme myeloperoxidase (MPO) is well known for its role in neutrophil extracellular traps. In a recent Nature work, Burn et al. now reveal for the first time MPO as a protein capable of modifying chromatin function into an immune effector, establishing a direct link between chromatin remodeling and innate immune defense.

https://doi.org/10.1038/s41422-025-01192-7

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