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ZBP1 links infections to cancer immunotherapy

Lorenzo Galluzzi^1,* , Spencer Brackett¹ , Neil Johnson^2,*

¹Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, PA, USA
²Nuclear Dynamics Program, Fox Chase Cancer Center, Philadelphia, PA, USA
* Correspondence: Lorenzo Galluzzi(deadoc80@gmail.com)Neil Johnson(neil.johnson@fccc.edu)

Z-DNA binding protein 1 (ZBP1) was thought to initiate necroptotic cell death in response to viral Z-RNA molecules. Recent data demonstrate that viral infection causes the accrual of endogenous Z-RNA species that are sufficient for ZBP1-driven necroptosis, opening the road to therapeutic strategies aimed at maximizing the immunogenicity of cancer cell death via necroptosis.

https://doi.org/10.1038/s41422-025-01196-3

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