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Mitochondria target the plasma membrane to cause mitoxyperiosis

Jaiya Randhawa , Luke A. J. O’Neill

School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
* Correspondence: Jaiya Randhawa(randhawj@tcd.ie)Luke A. J. O’Neill(laoneill@tcd.ie)

In a recent Cell paper, Wang and colleagues discovered a new type of cell death caused by contact between mitochondria and the plasma membrane, which they name mitoxyperiosis. Under Toll-like receptor (TLR) activation and metabolic stress, mTORC2 is activated, which in turn inhibits RhoA from supporting the actin network, thereby promoting mitochondrial migration to the plasma membrane; this allows for site-specific oxidative damage to the plasma membrane, causing cell lysis.

https://doi.org/10.1038/s41422-025-01215-3

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