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Asymmetric division rejuvenates stem cell lineages

Jianlong Wang

Department of Medicine, Columbia Center for Human Development, Columbia Center for Stem Cell Therapies, Columbia Stem Cell Initiative, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA
* Correspondence: Jianlong Wang(jw3925@cumc.columbia.edu)

Mouse embryonic stem cells maintain lineage immortality through sporadic entry into a two-cell-like state that enables asymmetric partitioning of DNA damage between daughter cells: one destined for elimination and one functionally rejuvenated.

https://doi.org/10.1038/s41422-026-01226-8

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