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IRES–cargo interplay structurally modulates circular RNA translation

Youkui Huang^1,† , Yao-Qi Chen^2,† , Si-Yu Lou^1,† , Xiang Gao^3,† , Yu-Xin Liu¹ , Yu-Lu Zhang³ , Fang Nan^1,2 , Ling-Ling Chen^1,4,5,6,* , Li Yang^2,*

¹State Key Laboratory of RNA Innovation, Science and Engineering, New Cornerstone Science Laboratory, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
²Center for Molecular Medicine, Children’s Hospital of Fudan University and Shanghai Key Laboratory of Medical Epigenetics, International Laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China
³Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, Zhejiang, China
⁴School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China
⁵School of Life Science and Technology, ShanghaiTech University, Shanghai, China
⁶Shanghai Academy of Natural Sciences (SANS), Shanghai, China
^†These authors contributed equally: Youkui Huang, Yao-Qi Chen, Si-Yu Lou, Xiang Gao
* Correspondence: Ling-Ling Chen(linglingchen@sibcb.ac.cn)Li Yang(liyang_fudan@fudan.edu.cn)

https://doi.org/10.1038/s41422-026-01233-9

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