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Borrowed mitochondria, spared neurons

Gwang-Bum Im^1,2 , Juan M. Melero-Martin^1,2,3,*

¹Department of Cardiac Surgery, Boston Children’s Hospital, Boston, MA, USA
²Department of Surgery, Harvard Medical School, Boston, MA, USA
³Harvard Stem Cell Institute, Cambridge, MA, USA
* Correspondence: Juan M. Melero-Martin(juan.meleromartin@childrens.harvard.edu)

Peripheral sensory neurons face extreme metabolic demands and are highly vulnerable to mitochondrial dysfunction in neuropathic pain. A recent Nature study by Xu et al. reveals that satellite glial cells actively protect these neurons by transferring mitochondria, uncovering a previously unrecognized mode of neuro–glial metabolic support.

https://doi.org/10.1038/s41422-026-01230-y

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