ADVANCE ONLINE PUBLICATION

RESEARCH HIGHLIGHTS

Carnitine biosynthesis governs fuel switching

Kyounghee Min , Philipp E. Scherer

Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA
* Correspondence: Philipp E. Scherer(Philipp.Scherer@UTSouthwestern.edu)

In a recent Science study, Auger and colleagues identified SLC25A45 as a previously unrecognized mitochondrial trimethyllysine (TML) transporter that enables l-carnitine biosynthesis. By regulating mitochondrial TML availability, SLC25A45 links environmental stressors such as cold exposure and fasting to adaptive fuel switching toward fatty acid oxidation, thereby optimizing mitochondrial energetics and metabolic resilience.

https://doi.org/10.1038/s41422-026-01229-5

FULL TEXT | PDF

Browse 12