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A lipid “glue” for STING oligomers

Zhiqi Sun¹ , Veit Hornung^1,2,*

¹Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany
²Cluster for Nucleic Acid Sciences and Technologies (NUCLEATE), Munich, Germany
* Correspondence: Veit Hornung(veit.hornung@lmu.de)

In a recent paper published in Nature, Tan et al. identify phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P₂) as an endogenous ligand that licenses cGAMP-induced STING activation. The study offers a mechanistic explanation on how full-scale STING signaling activation is coupled to its oligomerization on the post-Golgi compartment.

https://doi.org/10.1038/s41422-026-01243-7

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