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Lysosomal magneto-mechanics rewire immunity

Seyed Hossein Helalat , Marja Jäättelä

Cell Death and Metabolism, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Institute, Copenhagen, Denmark
* Correspondence: Seyed Hossein Helalat(seyedh@cancer.dk)Marja Jäättelä(mj@cancer.dk)

Mechanical cues at intracellular organelles are emerging as a parallel layer of immune regulation alongside biochemical signaling. A recent study published in Cell Research shows that programmable magneto-mechanical stimulation of lysosomes can integrate intracellular forces over time to durably reprogram macrophage polarization and antitumor immunity.

https://doi.org/10.1038/s41422-026-01236-6

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