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LETTERS TO THE EDITOR

GSK3α functions as a stemness checkpoint across multiple stem cell states

Duo Wang^1,2,†,* , Xiukun Wang^3,† , Safia Malki³ , Yanpui Chan¹ , Brian Bennett³ , Joshua Feng⁴ , Jiaqi Tang⁴ , Xi Chen¹ , Daniel McKim¹ , Chao Zhang⁴ , Litao Tao⁵ , Jie Xu² , Y. Eugene Chen² , Guang Hu^3,* , Qi-Long Ying^1,*

¹Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
²Center for Advanced Models Translational Sciences and Therapeutics, University of Michigan Medical School, Ann Arbor, MI, USA
³Epigenetics and RNA Biology Laboratory, National Institute of Environmental Health Sciences, Durham, NC, USA
⁴Loker Hydrocarbon Research Institute & Department of Chemistry, University of Southern California, Los Angeles, CA, USA
⁵Department of Biomedical Sciences, School of Medicine, Creighton University, Omaha, NE, USA
^†These authors contributed equally: Duo Wang, Xiukun Wang
* Correspondence: Duo Wang(wangduotc@gmail.com)Guang Hu(guang.hu@nih.gov)Qi-Long Ying(qying@med.usc.edu)

https://doi.org/10.1038/s41422-026-01245-5

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