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Structural and functional insights into HBx–Smc6 targeting for HBV inhibition

Tong Cheng^1,2,† , Jinhong Zhou^1,2,† , Wenjun Huang^3,† , Lili Du^1,2 , Pengyu He⁴ , Renzheng Yang¹ , Yan Gao⁵ , Menghan Hao³ , Kongying Hu³ , Jieliang Chen³ , Hongxia Wang⁶ , Zihe Rao^5,7,8,9,* , Zhenghong Yuan^3,* , Lanfeng Wang^1,2,4,10,*

¹Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
²College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China
³Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China
⁴College of Biological Science and Medical Engineering, Donghua University, Shanghai, China
⁵Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, China
⁶Department of Anesthesiology, University of California San Diego, La Jolla, CA, USA
⁷Laboratory of Structural Biology, Tsinghua University, Beijing, China
⁸State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences and College of Pharmacy, Nankai University, Tianjin, China
⁹National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Beijing, China
¹⁰The Key Laboratory of Molecular Biology of Infectious Diseases Designated by the Chinese Ministry of Education, Chongqing Medical University, Chongqing, China
^†These authors contributed equally: Tong Cheng, Jinhong Zhou, Wenjun Huang
* Correspondence: Zihe Rao(raozh@tsinghua.edu.cn)Zhenghong Yuan(zhyuan@shmu.edu.cn)Lanfeng Wang(lanfwang@simm.ac.cn)

https://doi.org/10.1038/s41422-026-01251-7

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