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Phosphatidylserine exposure and cancer immune evasion

Manuel Beltrán-Visiedo , Kerry S. Campbell , Lorenzo Galluzzi

Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, PA, USA
* Correspondence: Lorenzo Galluzzi(deadoc80@gmail.com)

Phosphatidylserine (PS) exposure on apoptotic cancer cells promotes their rapid and immunologically silent uptake by phagocytes, therefore favoring immune evasion. In a recent Nature study, evidence from viral infection models suggests that externalized PS also suppresses dendritic cell (DC) activation, adding to an expanding literature that identifies post-mitochondrial caspases as promising targets to inflame immunologically “cold” tumors.

https://doi.org/10.1038/s41422-026-01252-6

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