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RNA writes the nucleolus

Archit Gupta¹ , Eliezer Calo^1,2,*

¹Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
²Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA
* Correspondence: Eliezer Calo(calo@mit.edu)

Two studies recast nucleolar architecture as an emergent product of pre-rRNA transcription and processing, with the resulting layers feeding back to improve efficiency, quality control, and evolutionary fitness.

https://doi.org/10.1038/s41422-026-01259-z

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