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A neuronal basis for mental imagery

Stephen M. Fleming1,2,3,* , Nadine Dijkstra4

1Department of Experimental Psychology and Institute of Cognitive Neuroscience, University College London, London, UK
2Max Planck UCL Centre for Computational Psychiatry and Ageing Research, University College London, London, UK
3CIFAR Program in Brain, Mind and Consciousness, Toronto, ON, Canada
4Department of Imaging Neuroscience, University College London, London, UK
* Correspondence: Stephen M. Fleming(stephen.fleming@ucl.ac.uk)

Wadia et al. provide rare single-neuron evidence that mental imagery reactivates a perceptual code in the human ventral temporal cortex, with a substantial subset of object-tuned neurons showing shared tuning across seeing and imagining. By characterizing neuronal activity in a feature space derived from a deep neural network, the study demonstrates that imagery recapitulates the structure of perceptual representations.

https://doi.org/10.1038/s41422-026-01260-6

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