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Structural basis of the neuronal M-current generated by an asymmetric KCNQ2/3 assembly

Xinyu Cheng^1,2,† , Shuangyan Wan^1,2,†

¹The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, School of Basic Medical Sciences, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China
²Jiangxi Provincial Key Laboratory of Tumor Biology, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China
³Dr. Neher’s Biophysics Laboratory for Innovative Drug Discovery; State Key Laboratory of Mechanism and Quality of Chinese Medicine; School of Pharmacy, Faculty of Medicine; Faculty of Chinese Medicine, Macau University of Science and Technology, Macau SAR, China
⁴Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, School of Basic Medical Sciences, Gannan Medical University, Ganzhou, Jiangxi, China
⁵Shenzhen Crystalo Biopharmaceutical Co., Ltd, Shenzhen, Guangdong, China
⁶Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
⁷Macau University of Science and Technology Innovation Technology Research Institute, Hengqin, Guangdong, China
^†These authors contributed equally: Xinyu Cheng, Shuangyan Wan, Dexiang Jiang, Hangyu Zhang, Bin Hu
* Correspondence: 0

https://doi.org/10.1038/s41422-026-01261-5

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