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Releasing the stress brake on axon regeneration

Marc Hernaiz-Llorens¹ , Binhai Zheng^1,2,*

¹Department of Neurosciences, School of Medicine, University of California San Diego, La Jolla, CA, USA
²VA San Diego Research Service, San Diego, CA, USA
* Correspondence: Binhai Zheng(bizheng@health.ucsd.edu)

In a recent study published in Nature, Halawani et al. identify the aryl hydrocarbon receptor (AhR), a sensor of chemical and metabolic cues, as a key regulator of a stress-to-growth switch that suppresses axon regeneration after neural injury. These findings extend the role of bHLH-PAS transcription factors in regenerative control and highlight the importance of modulating stress responses to promote axonal repair.

https://doi.org/10.1038/s41422-026-01258-0

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