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TRAC in vivo: culmination of CAR and vector engineering

Annalisa Cabriolu , Michel Sadelain

Columbia Institute for Cell Engineering and Therapy (CICET), Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA
* Correspondence: Michel Sadelain(mws2188@cumc.columbia.edu)

In a recent Nature work, the first stable, T cell site-specific, in vivo integration of a CAR transgene was generated in mice, integrating a decade of T cell advances in TRAC remodeling, CAR signaling, and viral vector targeting to generate in a single infusion curative TRAC-CAR human T cells in tumor-bearing humanized mice.

https://doi.org/10.1038/s41422-026-01255-3

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