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Gut serotonin regulates Kupffer cell appetite for drug carriers

Peter A. A. Norris , Lili Zhai , Paul Kubes

Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON, Canada
* Correspondence: Paul Kubes(p.kubes@queensu.ca)

In a recent issue of Science, Wang et al. used mouse models to reveal a gut-liver immune axis where gut epithelium-derived serotonin increases liver Kupffer cell (KC) scavenging activity. This serotonin effect promotes the rapid clearance of various in vivo delivery systems (IDSs), limiting their effectiveness.

https://doi.org/10.1038/s41422-026-01263-3

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