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Liquid surrogates of spatial tumor ecosystems

Tian-Gen Chang^1,† , Eldad D. Shulman^2,† , Eytan Ruppin^2,*

¹Cancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA
²Translational Research Institute and Jim and Eleanor Randall Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA
^†These authors contributed equally: Tian-Gen Chang, Eldad D. Shulman
* Correspondence: Eytan Ruppin(Eytan.Ruppin@csmc.edu)

Spatially organized tumor ecosystems leave methylation footprints that are partly detectable in blood.

https://doi.org/10.1038/s41422-026-01270-4

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