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Why microglial repair programs fade

Yvonne L. Latour , Dorian B. McGavern

Viral Immunology and Intravital Imaging Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, MD, USA
* Correspondence: Dorian B. McGavern(mcgavernd@mail.nih.gov)

Why spontaneous recovery eventually stalls after stroke remains unclear. Tsuyama and colleagues identify a ZFP384-dependent mechanism that terminates reparative microglial programs and show that preserving these injury-induced states prolongs endogenous brain repair and functional recovery after ischemic stroke.

https://doi.org/10.1038/s41422-026-01278-w

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