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Galvanin: a molecular compass for bioelectric navigation

Bishwa Ranjan Si^1,2,† , Debanik Choudhury^1,2,† , Sanjiban Nath^1,2,† , Konstantinos Konstantopoulos^1,2,3,4,*

¹Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD, USA
²Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, MD, USA
³Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD, USA
⁴Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
^†These authors contributed equally: Bishwa Ranjan Si, Debanik Choudhury, Sanjiban Nath
* Correspondence: Konstantinos Konstantopoulos(konstant@jhu.edu)

Belliveau and colleagues developed a CRISPRi-based electrotaxis screening platform to identify Galvanin/TMEM154 as a novel electric field (EF) sensor in immune cells and keratocytes. Galvanin's negatively charged ectodomain is sufficient for EF sensing, whereas its intracellular domain regulates downstream signaling and directed migration. This work opens new avenues for uncovering molecular sensors of EF-guided directed migration across diverse cell types.

https://doi.org/10.1038/s41422-026-01279-9

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