Volume 22, No 10, Oct 2012

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 22 Issue 10, October 2012: 1407-1409

RESEARCH HIGHLIGHTS

Crystal structure of IFIT2 (ISG54) predicts functional properties of IFITs

Ganes C Sen and Volker Fensterl

Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic, OH 44195, USA Correspondence: Ganes C Sen(seng@ccf.org)

Interferon carries out its cellular effects, including its antiviral effects, by inducing the synthesis of many new proteins, amongst which is the IFIT (ISG56) family of proteins. The first crystal structure of an IFIT, reported by Yang et al., revealed several functional properties of the protein that may help us to better understand the biological functions of these proteins.

Cell Research (2012) 22:1407-1409. doi:10.1038/cr.2012.130; published online 11 September 2012

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