Volume 22, No 10, Oct 2012

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 22 Issue 10, October 2012: 1410-1412

RESEARCH HIGHLIGHTS

A finger on the pulse of Wnt receptor signaling

Bryan T MacDonald and Xi He

The F. M. Kirby Neurobiology Center, Boston Children's Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA Correspondence: Xi He(xi.he@childrens.harvard.edu)

In a recent issue of Nature, Hao et al. report an unexpected link between the secreted stem cell factor/Wnt agonist R-spondin and Wnt receptors through the transmembrane ZNRF3 protein, a RING finger ubiquitin ligase. ZNRF3 acts to turn over Frizzled and LRP6 receptors. R-spondin binds to ZNRF3, in addition to transmembrane LGR4/5 receptors, to antagonize degradation of the Wnt receptors by ZNRF3, thereby resulting in increased Frizzled and LRP6 levels and a greater Wnt response.

Cell Research (2012) 22:1410-1412. doi:10.1038/cr.2012.91; published online 12 June 2012

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