Volume 23, No 1, Jan 2013

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 23 Issue 1, January 2013: 6-9

RESEARCH HIGHLIGHTS

PGC7, H3K9me2 and Tet3: regulators of DNA methylation in zygotes

Jinsuk Kang¹, Sundeep Kalantry² and Anjana Rao¹

¹La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
²Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA Correspondence: Anjana Rao,(arao@liai.org)

In zygotes, a global loss of DNA methylation occurs selectively in the paternal pronucleus before the first cell division, concomitantly with the appearance of modified forms of 5-methylcytosine. The adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Nakamura et al. recently clarified the molecular mechanism involved: PGC7/Stella/Dppa3 binds to dimethylated histone 3 lysine 9 (H3K9me2), thereby blocking the activity of the Tet3 methylcytosine oxidase in the maternal genome as well as at certain imprinted loci in the paternal genome.

Cell Research (2013) 23:6-9. doi:10.1038/cr.2012.117; published online 7 August 2012

FULL TEXT | PDF

Browse 4881