Volume 23, No 1, Jan 2013

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 23 Issue 1, January 2013: 10-12

RESEARCH HIGHLIGHTS

The controversial role of Sirtuins in tumorigenesis — SIRT7 joins the debate

Ling Li and Ravi Bhatia

Division of Hematopoietic Stem cell and Leukemia Research, City of Hope National Medical Center, Duarte, CA 91010, USA Correspondence: Ravi Bhatia(rbhatia@coh.org)

Sirtuins are NAD-dependent deacetylases that are conserved from yeast to mammals. A new report sheds light on the function of SIRT7, the least understood member of the Sirtuin family by identifying its locus-specific H3K18 deacetylase activity, and linking it to maintenance of cellular transformation in malignancies.

Cell Research (2013) 23:10-12. doi:10.1038/cr.2012.112; published online 31 July 2012

FULL TEXT | PDF

Browse 4679