Volume 23, No 1, Jan 2013

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 23 Issue 1, January 2013: 49-69

REVIEWS

Embryonic stem cell and induced pluripotent stem cell: an epigenetic perspective

Gaoyang Liang^1,2,3 and Yi Zhang^1,2,3,4,5

¹Howard Hughes Medical Institute, Harvard Medical School, WAB-149G, 200 Longwood Avenue, Boston, MA 02115, USA
²Program in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, WAB-149G, 200 Longwood Avenue, Boston, MA 02115, USA
³Department of Genetics, Harvard Medical School, WAB-149G, 200 Longwood Avenue, Boston, MA 02115, USA
⁴Department of Pediatrics, Harvard Medical School, WAB-149G, 200 Longwood Avenue, Boston, MA 02115, USA
⁵Harvard Stem Cell Institute, Harvard Medical School, WAB-149G, 200 Longwood Avenue, Boston, MA 02115, USA Correspondence: Yi Zhang(yzhang@genetics.med.harvard.edu)

Pluripotent stem cells, like embryonic stem cells (ESCs), have specialized epigenetic landscapes, which are important for pluripotency maintenance. Transcription factor-mediated generation of induced pluripotent stem cells (iPSCs) requires global change of somatic cell epigenetic status into an ESC-like state. Accumulating evidence indicates that epigenetic mechanisms not only play important roles in the iPSC generation process, but also affect the properties of reprogrammed iPSCs. Understanding the roles of various epigenetic factors in iPSC generation contributes to our knowledge of the reprogramming mechanisms.

Cell Research (2013) 23:49-69. doi:10.1038/cr.2012.175; published online 18 December 2012

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