Volume 22, No 12, Dec 2012

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 22 Issue 12, December 2012: 1617-1620

RESEARCH HIGHLIGHTS

LKB1-AMPK axis revisited

Filippos Kottakis and Nabeel Bardeesy

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA Correspondence: Nabeel Bardeesy,(bardeesy.nabeel@mgh.harvard.edu)

The LKB1 tumor suppressor encodes a serine-threonine kinase whose substrates control cell metabolism, polarity, and motility. LKB1 is a major mediator of the cellular response to energy stress via activation of the master regulator of energy homeostasis, AMPK. While mutational inactivation of LKB1 promotes the development of many types of epithelial cancer, a recent report in Nature by Jeon et al. demonstrates that the LKB1-AMPK pathway can also have an unexpected positive role in tumorigenesis, acting to maintain metabolic homeostasis and attenuate oxidative stress thereby supporting the survival of cancer cells.

Cell Research (2012) 22:1617-1620. doi:10.1038/cr.2012.108; published online 17 July 2012

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