Volume 22, No 12, Dec 2012
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 22 Issue 12, December 2012: 1627-1630
RESEARCH HIGHLIGHTS
Huntington's disease: Dancing in a dish
Kejing Zhang1,*, Fei Yi1,*, Guang-Hui Liu1,2 and Juan Carlos Izpisua Belmonte1,3
1Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
2National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
3Center for Regenerative Medicine in Barcelona, Dr. Aiguader 88, 08003 Barcelona, Spain
Correspondence: Guang-Hui Liu,Juan Carlos Izpisua Belmonte,(ghliu@ibp.ac.cn;belmonte@salk.edu, izpisua@cmrb.eu)
In a recent landmark paper, the Huntington's disease (HD) iPSC Consortium reports on the establishment and characterization of a panel of iPSC lines from HD patients, and more importantly, the successful modeling of HD in vitro. In the same issue of Cell Stem Cell, An et al. reports on the successful targeted gene correction of HD in human iPSCs. Both advances are exciting, provide new resources for current and future HD research, and uncover new challenges to better understand and, most importantly, treat this devastating disease in the near future.
Cell Research (2012) 22:1627-1630. doi:10.1038/cr.2012.116; published online 7 August 2012
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