Volume 22, No 12, Dec 2012

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 22 Issue 12, December 2012: 1631-1633

RESEARCH HIGHLIGHTS

Salicylic acid binds NPR3 and NPR4 to regulate NPR1-dependent defense responses

Magali Moreau*, Miaoying Tian* and Daniel F Klessig

Boyce Thompson Institute for Plant Research, Ithaca, NY 14853, USA Correspondence: Daniel F Klessig,(dfk8@cornell.edu)

Salicylic acid (SA) is widely recognized as a key player in plant immunity. While several proteins have been previously identified as the direct targets of SA, SA-mediated plant defense signaling mechanisms remain unclear. The Nature paper from Xinnian Dong's group demonstrates that the NPR1 paralogues NPR3 and NPR4 directly bind SA, and this binding modulates their interaction with NPR1 and thereby degradation of this key positive regulator of SA-mediated defense, shedding important new insight into the mechanism(s) of SA-mediated, NPR1-dependent plant defense signal transduction.

Cell Research (2012) 22:1631-1633. doi:10.1038/cr.2012.100; published online 26 June 2012

FULL TEXT | PDF

Browse 2668