Volume 22, No 12, Dec 2012

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 22 Issue 12, December 2012: 1634-1636

RESEARCH HIGHLIGHTS

Versatility of the translational machinery during stress: changing partners to keep dancing

Fátima Gebauer

Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation (CRG-UPF), Dr Aiguader 88, 08003-Barcelona, Spain Correspondence: Fátima Gebauer,(fatima.gebauer@crg.eu)

Cap-dependent translation is initiated by the binding of eIF4E to the cap structure at the 5′ end of mRNAs. During hypoxic stress, global translation decreases because eIF4E is inactivated. In a recent article in Nature, Lee and colleagues show that residual hypoxic translation is maintained by a specialized isoform of eIF4E, which binds to target mRNAs in complex with a hypoxia-induced RNP.

Cell Research (2012) 22:1634-1636. doi:10.1038/cr.2012.102; published online 3 July 2012

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