Volume 22, No 11, Nov 2012

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 22 Issue 11, November 2012: 1512-1514

RESEARCH HIGHLIGHTS

Pull and push: Talin activation for integrin signaling

Jia-huai Wang^1,2

¹College of Life Sciences, Peking University, Beijing 100871, China
²Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA Correspondence: Jia-huai Wang,(jwang@red.dfci.harvard.edu)

The inside-out signaling of integrins regulates the ligand-binding affinity of the cell surface receptors in response to changes in the environment for cell survival. The specific binding to the cytoplasmic tail of integrin's β subunit by the intracellular protein talin is the key step of inside-out signaling. A “pull-push” mechanism has been proposed to explain how the PIP2-enriched membrane disrupts the dual auto-inhibition of the N-terminal talin-FERM domain by the C-terminal talin-rod domain such that activated talin-FERM can reach the β-tail for integrin activation.

Cell Research (2012) 22:1512-1514. doi:10.1038/cr.2012.103; published online 10 July 2012

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