Volume 22, No 11, Nov 2012

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 22 Issue 11, November 2012: 1515-1517

RESEARCH HIGHLIGHTS

A new paradigm in viral resistance

Autumn Ruiz and Stephen J Russell

Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA Correspondence: Stephen J Russell,(sjr@mayo.edu)

The rapid mutation of RNA viruses allows for the acquisition of resistance to drugs directly targeting viral proteins. Therefore, a novel approach to the development of antivirals centers on targeting host factors critical to viral replication. A recent report has brought to light the potential for RNA viruses to also develop resistance against compounds targeting crucial host factors, suggesting that a combination of drugs with various targets may be necessary for preventing resistance.

Cell Research (2012) 22:1515-1517. doi:10.1038/cr.2012.139; published online 2 October 2012

FULL TEXT | PDF

Browse 2157