Volume 22, No 11, Nov 2012

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 22 Issue 11, November 2012: 1518-1520

RESEARCH HIGHLIGHTS

Indigestible mitochondria cause heartburn

Roberta A Gottlieb and Phyllis-Jean Linton

Donald P. Shiley BioScience Center, San Diego State University, San Diego, CA 92182, USA Correspondence: Roberta A Gottlieb,(robbieg@sciences.sdsu.edu)

The link between impaired autophagic flux (autophagus interruptus), damaged mitochondria, and myocardial inflammation has been further tightened with the recent paper by Oka and colleagues, in which failure to degrade mitochondrial DNA exacerbated myocardial inflammation in the context of pressure overload. Using mice with cardiac-specific deletion of the lysosomal DNase II that were subjected to aortic banding, Otsu's group showed that mitochondrial DNA accumulated in lysosomes and resulted in TLR9-dependent production of inflammatory cytokines.

Cell Research (2012) 22:1518-1520. doi:10.1038/cr.2012.96; published online 19 June 2012

FULL TEXT | PDF

Browse 2237