Volume 22, No 11, Nov 2012

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 22 Issue 11, November 2012: 1524-1526

RESEARCH HIGHLIGHTS

Releasing the break on X chromosome inactivation: Rnf12/RLIM targets REX1 for degradation

Ingolf Bach^1,2

¹Program in Gene Function & Expression, University of Massachusetts Medical School, Worcester, MA 01605, USA
²Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA Correspondence: Ingolf Bach,(ingolf.bach@umassmed.edu)

One of the two X chromosomes in cells of female mammals is transcriptionally silenced in a process known as X chromosome inactivation (XCI). Initiation of XCI is regulated by the ubiquitin ligase Rnf12/RLIM, but the mechanisms by which Rnf12/RLIM mediates this process has been a mystery. A recent study by Gontan et al. shows that Rnf12/RLIM targets REX1, an inhibitor of XCI, for proteasomal degradation, providing an answer to this question.

Cell Research (2012) 22:1524-1526. doi:10.1038/cr.2012.98; published online 26 June 2012

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