Volume 22, No 11, Nov 2012

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 22 Issue 11, November 2012: 1527-1529

RESEARCH HIGHLIGHTS

Epithelial self-defense against cancer

Hajime Yamauchi and Yasuyuki Fujita

Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, North 15 West 7, Kita-ku, Sapporo, Hokkaido 060-0815, Japan Correspondence: Yasuyuki Fujita,(yasu@igm.hokudai.ac.jp)

It is not clearly understood what happens at the interface between normal and transformed epithelial cells at the first step of carcinogenesis. A recent study reveals that the organized epithelial structure suppresses clonal expansion of transformed cells. Translocation from the epithelium or perturbation of intercellular adhesions may be required for transformed cells to evade the suppressive environments.

Cell Research (2012) 22:1527-1529. doi:10.1038/cr.2012.69; published online 24 April 2012

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