Volume 22, No 10, Oct 2012
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 22 Issue 10, October 2012: 1416-1418
RESEARCH HIGHLIGHTS
The PPARγ-FGF1 axis: an unexpected mediator of adipose tissue homeostasis
Kai Sun1 and Philipp E Scherer1,2
1Touchstone Diabetes Center, Departments of Internal Medicine, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
2Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Correspondence: Philipp E Scherer,(Philipp.Scherer@utsouthwestern.edu)
Adipose tissue remodeling is a dynamic process during nutritional fluctuation that plays critical roles in metabolic homeostasis and insulin sensitivity. The process is highly regulated by many factors, including adipokines and cytokines that are locally released within fat pads. In a recent study published in Nature, Jonker and colleagues identified FGF1 as an important mediator that is selectively induced in fat cells by high-fat diet feeding and established the PPARγ-FGF1 axis as a critical pathway that regulates adipose tissue remodeling and ultimately systemic metabolic homeostasis.
Cell Research (2012) 22:1416-1418. doi:10.1038/cr.2012.94; published online 19 June 2012
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