Volume 22, No 10, Oct 2012

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 22 Issue 10, October 2012: 1419-1421

RESEARCH HIGHLIGHTS

PABPN1 shuts down alternative poly(A) sites

Martine Simonelig

mRNA Regulation and Development, Institute of Human Genetics, CNRS UPR1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France Correspondence: Martine Simonelig,(Martine.Simonelig@igh.cnrs.fr)

Although overlooked for many years, alternative cleavage and polyadenylation (APA) is now emerging as a major mechanism of gene regulation. A recent study identifies poly(A)-binding protein nuclear 1 (PABPN1), a general factor of polyadenylation, as a suppressor of alternative poly(A) sites.

Cell Research (2012) 22:1419-1421. doi:10.1038/cr.2012.86; published online 29 May 2012

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