Volume 22, No 10, Oct 2012

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 22 Issue 10, October 2012: 1426-1428

RESEARCH HIGHLIGHTS

A tale of three GTPases and a RIN in endothelial cell adhesion

Mar Fernandez-Borja

Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Correspondence: Mar Fernandez-Borja,(m.fernandez@sanquin.nl)

Endothelial cell adhesion to the extracellular matrix regulates migration and outgrowth of blood vessels during angiogenesis. Cell adhesion is mediated by integrins, which transduce signals from the extracellular environment into the cell and, in turn, are regulated by intracellular signaling molecules. In a paper recently published in Cell Research, Sandri et al. show that RIN2 connects three GTPases, R-Ras, Rab5 and Rac1, to promote endothelial cell adhesion through the regulation of integrin internalization and Rac1 activation.

Cell Research (2012) 22:1426-1428. doi:10.1038/cr.2012.118; published online 14 August 2012

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