Volume 22, No 9, Sep 2012

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 22 Issue 9, September 2012: 1309-1311

RESEARCH HIGHLIGHTS

New secrets behind bone metastasis

Xing Guo¹ and Xiao-Fan Wang²

¹Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA
²Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA Correspondence: Xing Guo, Xiao-Fan Wang,(x4guo@ucsd.edu; xiao.fan.wang@duke.edu)

Secreted proteins play essential roles in every step of cancer metastasis, while the identities and functions of those that contribute to tissue-specific metastasis are largely uncharacterized. Two articles in Cell Research report the discovery and functional analyses of novel secreted proteins that are biologically and clinically relevant to bone metastasis. The combinatory approaches represented here, together with advances in related technology, will promise a better understanding of the cancer secretome.

Cell Research (2012) 22:1309-1311. doi:10.1038/cr.2012.99; published online 26 June 2012

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