Volume 22, No 9, Sep 2012

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 22 Issue 9, September 2012: 1315-1318

RESEARCH HIGHLIGHTS

Found in translation of mTOR signaling

John G Clohessy*, Markus Reschke* and Pier Paolo Pandolfi

Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA Correspondence: Pier Paolo Pandolfi,(ppandolf@bidmc.harvard.edu)

The mammalian target of rapamycin (mTOR) protein kinase regulates a wide variety of cellular processes, including protein synthesis, yet the downstream translational program under the control of mTOR is poorly understood. Two recent studies by Hsieh et al. and Thoreen et al. now start to address this issue, and uncover a subset of genes translationally regulated by oncogenic mTOR signaling that may contribute to tumorigenesis.

Cell Research (2012) 22:1315-1318. doi:10.1038/cr.2012.85; published online 29 May 2012

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