Volume 22, No 9, Sep 2012

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 22 Issue 9, September 2012: 1319-1321

RESEARCH HIGHLIGHTS

REV-ERB-erating nuclear receptor functions in circadian metabolism and physiology

Jürgen A Ripperger and Urs Albrecht

Department of Biology, Unit of Biochemistry, University of Fribourg, Chemin du Musée 5, 1700 Fribourg, Switzerland Correspondence: Urs Albrecht,(urs.albrecht@unifr.ch)

A hallmark of the mammalian circadian timing system is synchronization of physiology and behavior, but when this synchronization is disturbed, chronic diseases such as metabolic syndrome and depression may develop. Three new studies show that nuclear receptors of the Rev-Erb family impact the circadian oscillator and its metabolic output and this can be modified with specific agonists. Hence, resynchronization of metabolic pathways by manipulation of the circadian oscillator using REV-ERB-specific agonists may represent a feasible therapeutic concept to target diseases rooted in a misaligned circadian system.

Cell Research (2012) 22:1319-1321. doi:10.1038/cr.2012.81; published online 22 May 2012

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