Volume 22, No 9, Sep 2012
ISSN: 1001-0602
EISSN: 1748-7838 2018
impact factor 17.848*
(Clarivate Analytics, 2019)
Volume 22 Issue 9, September 2012: 1322-1324
RESEARCH HIGHLIGHTS
What comes first: translational repression or mRNA degradation? The deepening mystery of microRNA function
Wenqian Hu1 and Jeff Coller2
1Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
2Center for RNA Molecular Biology, Case Western Reserve University, Cleveland, OH 44106, USA
Correspondence: Jeff Coller,(jmc71@case.edu)
While many mechanisms have been proposed for microRNAs (miRNAs) function, most ultimately cause message degradation. A view has emerged that miRNAs silence gene expression by promoting the association of mRNA decay factors. Recent research results, however, suggest that in both zebrafish and fruit fly, translational inhibition is the initiating event of miRNA-mediated gene silencing.
Cell Research (2012) 22:1322-1324. doi:10.1038/cr.2012.80; published online 22 May 2012
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