Volume 22, No 8, Aug 2012

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 22 Issue 8, August 2012: 1207-1209

RESEARCH HIGHLIGHTS

Leucyl-tRNA synthetase: double duty in amino acid sensing

Raúl V Durán and Michael N Hall

Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland Correspondence: Michael N Hall,(m.hall@unibas.ch)

The cellular response to amino acids is controlled at the molecular level by TORC1. While many of the elements that participate in TORC1 signaling are known, we still have no clear idea how cells sense amino acids. Two recent studies found that leucyl-tRNA synthetase (LRS) is a leucine sensor for TORC1, in both yeast and mammalian cells.

Cell Research (2012) 22:1207-1209. doi: 10.1038/cr.2012.68; published online 24 April 2012

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