Volume 22, No 8, Aug 2012

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 22 Issue 8, August 2012: 1224-1226

RESEARCH HIGHLIGHTS

CUL4B ubiquitin ligase in mouse development: A model for human X-linked mental retardation syndrome?

Yongchao Zhao and Yi Sun

Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan, 4424B MS-1, 1301 Catherine Street, Ann Arbor, MI 48109, USA Correspondence: Yi Sun,(sunyi@umich.edu)

CUL4B, a member of the cullin-RING ubiquitin ligase family, is frequently mutated in X-linked mental retardation (XLMR) patients. The study by Liu et al. showed that Cul4b plays an essential developmental role in the extra-embryonic tissues, while it is dispensable in the embryo proper during mouse embryogenesis. Viable Cul4b-null mice provide the first animal model to study neuronal and behavioral deficiencies seen in human CUL4B XLMR patients.

Cell Research (2012) 22:1224-1226. doi:10.1038/cr.2012.79; published online 15 May 2012

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