Volume 22, No 7, Jul 2012

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 22 Issue 7, July 2012: 1092-1094

RESEARCH HIGHLIGHTS

The role of LRRK2 in inflammatory bowel disease

Zhihua Liu¹ and Michael J Lenardo²

¹Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
²Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1892, USA Correspondence: Michael J Lenardo,(lenardo@nih.gov)

LRRK2 was recently identified as a major susceptibility gene for Crohn's disease (CD) by genome-wide association studies (GWAS). LRRK2 deficiency in mice confers enhanced susceptibility to experimental colitis. In this research highlight, we discuss the current understanding of LRRK2 in the context of colitis, and postulate the future directions.

Cell Research (2012) 22:1092-1094. doi:10.1038/cr.2012.42; published online 20 March 2012

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