Volume 22, No 7, Jul 2012

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 22 Issue 7, July 2012: 1099-1101

RESEARCH HIGHLIGHTS

NLRC5: a NOD-like receptor protein with many faces in immune regulation

Yue Zhao and Feng Shao

National Institute of Biological Sciences, 7# Science Park Rd, Zhongguancun Life Science Park, Beijing 102206, China Correspondence: Feng Shao,(shaofeng@nibs.ac.cn)

Intracellular NOD-like receptor (NLR) proteins are believed to play important roles in innate immune detection or immune regulation, but only a few NLR proteins are functionally defined. Recent intensive studies, largely in vitro, on NLRC5 reveal multiple and controversial roles of this NLR protein in signaling regulation of both innate and adaptive immune responses. Using independently generated Nlrc5-deficient mice, two studies have now established the physiological function of NLRC5 in transcriptional control of MHC class I molecules despite that its role in innate immune signaling remains to be further clarified.

Cell Research (2012) 22:1099-1101. doi:10.1038/cr.2012.83; published online 22 May 2012

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