Volume 22, No 6, Jun 2012

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 22 Issue 6, June 2012: 948-949

RESEARCH HIGHLIGHTS

MLL-AF4 driven leukemogenesis: what are we missing?

Ronald W Stam

Department of Pediatric Oncology/Haematology, Erasmus MC-Sophia Children's Hospital, Dr. Molewaterplein 50, Room: Ee15-14a, 3015 GE Rotterdam, The Netherlands Correspondence: Ronald W Stam,(r.stam@erasmusmc.nl)

Pre-leukemic MLL-AF4 fusions arise prenatally and typically lead to overt acute lymphoblastic leukemia (ALL) at or shortly after birth. In a recent study, Bueno and colleagues explored the effects of MLL-AF4 expression in human embryonic stem cells (hESCs), with a focus on early hemato-endothelial development.

Cell Research (2012) 22:948-949. doi:10.1038/cr.2012.16; published online 31 January 2012

FULL TEXT | PDF

Browse 1967