Volume 22, No 6, Jun 2012

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 22 Issue 6, June 2012: 950-953

RESEARCH HIGHLIGHTS

MIF and autophagy: a novel link beyond

Omar El Bounkari and Jürrgen Bernhagen

Institute of Biochemistry & Molecular Cell Biology, RWTH Aachen University, Pauwelsstrasse 30, D-52074 Aachen, Germany Correspondence: Jürrgen Bernhagen,(jbernhagen@ukaachen.de)

Macrophage migration inhibitory factor (MIF) is overexpressed in numerous tumors and has been correlated with the development of breast cancer, but the mechanism(s) have largely remained unknown. Suppression of autophagy has now been unraveled as a pivotal mechanism underlying MIF's role in breast cancer. Strikingly, the study demonstrates that MIF phenocopies the anti-autophagic effects of steroid receptor coactivator-3 (SRC-3), a known oncogene, which in turn drives MIF gene expression.

Cell Research (2012) 22:950-953. doi:10.1038/cr.2012.76; published online 8 May 2012

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