Volume 22, No 5, May 2012

ISSN: 1001-0602 
EISSN: 1748-7838 2018 
impact factor 17.848* 
(Clarivate Analytics, 2019)

Volume 22 Issue 5, May 2012: 783-785

RESEARCH HIGHLIGHTS

Self-eating with your fingers

Daniel J Klionsky¹ and James H Hurley²

¹Life Sciences Institute, and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
²Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA Correspondence: Daniel J Klionsky, James H Hurley,(klionsky@umich.edu; hurley@helix.nih.gov)

BECN1 plays a central role in determining cell fate, acting as a balance point in the decision to undergo autophagy or apoptosis. Three distinct structural domains allow BECN1 to interact with several other proteins. Recent crystallographic data provide insight into the nature of the coiled-coil and evolutionarily conserved domains.

Cell Research (2012) 22:783-785. doi:10.1038/cr.2012.39; published online 13 March 2012

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